Selenium, cadmium and diazinon insecticide in tissues of rats after peroral exposure


  • Róbert Toman Robert Toman, Slovak University of Agriculture, Faculty of Agrobiology and Food Sources, Department of Veterinary Disciplines, Tr. A. Hlinku 2, 949 76 Nitra
  • Martina Tunegová Robert Toman, Slovak University of Agriculture, Faculty of Agrobiology and Food Sources, Department of Veterinary Disciplines, Tr. A. Hlinku 2, 949 76 Nitra



cadmium, selenium, diazinon, tissue, rat


The concentrations of selenium (Se), cadmium (Cd) and diazinon (DZN) in selected tissues of rats after an oral administration in various combinations were analyzed. Male rats were orally dosed with diazinon (40 mg.L-1), diazinon (40 mg.L-1) +selenium (5 mg.L-1), diazinon (40 mg.L-1) +cadmium (30 mg.L-1), and diazinon (40 mg.L-1) +selenium (5 mg.L-1) +cadmium (30 mg.L-1) in drinking water. After 90 days of per oral administration of compounds, the samples of liver, kidney, muscle tissue (m. quadriceps femoris), and adipose tissue were collected. The content of DZN was analyzed using Gas Chromatography - Mass Spectrometry (GC-MS), Cd was analyzed using an Electrothermal Atomic Absorption Spectrometry (ETAAS) and Se using a Hydride Generation Atomic Absorption Spectrometry (HG-AAS) methods. Cadmium significantly increased in liver and kidney after DZN +Cd and DZN +Se +Cd administration. Se significantly increased in liver of DZN +Se, DZN +Se +Cd and DZN +Cd exposed rats, in kidney of DZN +Se and DZN +Se +Cd and DZN +Cd, and in muscle of DZN +Se +Cd group. Highest DZN content was found in the adipose tissue in DZN, DZN +Cd and DZN +Se +Cd but not in combined exposure with Se. Anyway, the differences between the control and experimental groups were not significant. The results indicate that cadmium and selenium accumulate mainly in liver, kidney and selenium also in muscle after p.o. administration but diazinon concentrations increases were not signifcant. The co-administration of diazinon, Se and Cd affects the content of these compounds in the organism and the accumulation rate depends on the combination of administered compounds. Diazinon and cadmium could contribute to the selenium redistribution in the organism after the peroral intake.


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How to Cite

Toman, R. ., & Tunegová, M. . (2017). Selenium, cadmium and diazinon insecticide in tissues of rats after peroral exposure. Potravinarstvo Slovak Journal of Food Sciences, 11(1), 718–724.

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