The study of the cytotoxic effect of disinfectants

Authors

  • Olha Iakubchak National University of Life and Environmental Sciences of Ukraine, Faculty of Veterinary Medicine, Department of Veterinary Hygiene, Heroiv Oborony Str., 15, 03041, Kyiv, Ukraine https://orcid.org/0000-0002-9390-6578
  • Lida Adamenko Separate Structural Subdivision, Kozelets Professional College of Veterinary Medicine of Bila Tserkva National Agrarian University” 41, Simyi Rozumovskyh St., 17000, Kozelets, Chernihiv oblast https://orcid.org/0000-0002-6746-2846
  • Tetiana Taran National University of Life and Environmental Sciences of Ukraine, Faculty of Veterinary Medicine, Department of Veterinary Hygiene, Heroiv Oborony St., 15, 03041 Kyiv, Ukraine https://orcid.org/0000-0002-9370-8539
  • Olena Sydorenko State University of Trade and Economics / Kyiv National University of Trade and Economics, Faculty of Trade and Marketing, Department Commodity Science, Safety and Quality Management, 19, Kyoto str., Kyiv-156, 02156, Ukraine, Tel.: +380961266949
  • Tatyana Rozbytska National University of Life and Environmental Sciences of Ukraine, Faculty of foodtechnologies and quality management of products of agricultural products, Department of Standardization and certifying of agricultural products, Heroiv Oborony Str.15, 03041, Kyiv, Ukraine https://orcid.org/0000-0003-0098-927X
  • Nina Tverezovska National University of Life and Environmental Sciences of Ukraine, Faculty of Humanities and Pedagogy, Department of Social Work and Rehabilitation, Heroes of Defense, Str.15, 03041 Kyiv, Ukraine, Tel.: +38(044) 527-83-57 https://orcid.org/0000-0002-0672-9308
  • Valentyna Israelian National University of Life and Environmental Sciences of Ukraine, Faculty of Food Technology and Quality Control of Agricultural Products, Department of Technology of meat, fish and marine products, Polkovnyka Potiekhina Str., 16, Kyiv, 03040, Ukraine, Tel.: +38(096)724-03-99
  • Nataliia Holembovska National University of Life and Environmental Sciences of Ukraine, Faculty of Food Technology and Quality Control of Agricultural Products, Department of Technology of meat, fish and marine products, Polkovnyka Potiekhina Str., 16, Kyiv, 03040, Ukraine, Tel.: +38(096)206-62-76 https://orcid.org/0000-0001-8159-4020
  • Alina Menchynska The National University of Life and Environmental Sciences of Ukraine, Faculty of Food Technology and Quality Control of Agricultural Products, Department of Technology of meat, fish and marine products, Polkovnika Potekhina Str., 16, 03040, Kyiv, Ukraine, Tel.: +38(097)658-38-88
  • Anastasiia Ivaniuta National University of Life and Environmental Sciences of Ukraine, Faculty of Food Technology and Quality Control of Agricultural Products, Department of Technology of meat, fish and marine products, Polkovnika Potekhina Str., 16, Kyiv, 03040, Ukraine https://orcid.org/0000-0002-1770-5774

DOI:

https://doi.org/10.5219/1822

Keywords:

toxicity, cell culture, in vitro, disinfectant, genotoxicity

Abstract

The toxicity of individual disinfectants has been studied in vitro using human cell cultures (HT-29 (epithelial-like cells of colon adenocarcinoma), HEK 293 (human embryonic kidney cells)) to create a model for assessing the toxicity of residual amounts of disinfectants that can enter milk for a person. Standard tests have been used to assess cell viability and amount: methyl tetrazolium (MTT) test, neutral red cell staining (NRP), and sulforhodamine B (SRB) test. Disinfectants have a dose- and time-dependent cytotoxic effect on human cell cultures. IC50avg (concentration of the drug that suppresses a certain cell function by 50%) of disinfectants based on the effect on cell cultures (average value) is Biodez – 117.29 ±14 μl/l, Blanidas – 389.25 ±20.83 μl/l, Virkon-S – 343.04 ±28.04 μl/l, Neochlor  – 473.82 ±30.16 μl/l, Phan – 56.71 ±7.05 μl/l, Chlorination – 343.28 ±27.26 μl/l, Chlorinated lime – 117.35 ±9.44 μl/l. Mean toxic doses for cell cultures are lower than the mean lethal dose (based on literature data) for rats and mice by gastric administration. The novelty is that determining the cytotoxicity of disinfectants in vitro using human cell cultures can significantly reduce the number of animals for establishing LD50 during the registration procedure of new agents, making it possible to make preliminary conclusions about the toxicity of substances at the stage of chemical screening, preliminary hygienic regulation, identify target organs of toxic influence.

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2023-02-27

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Iakubchak, O., Adamenko, L., Taran, T., Sydorenko, O., Rozbytska, T., Tverezovska, N., Israelian, V., Holembovska, N., Menchynska, A., & Ivaniuta, A. (2023). The study of the cytotoxic effect of disinfectants. Potravinarstvo Slovak Journal of Food Sciences, 17, 82–95. https://doi.org/10.5219/1822

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