The improvement of insulin resistance and the antioxidant capacity in type 2 diabetes mellitus rats with whiteleg shrimp shell powder (Litopenaeus vannamei)

Authors

  • Risya Ahriyasna Universitas Diponegoro and Universitas Perintis Indonesia, Faculty of Medicine and Health Sciences, Department of Nutritional Science, Adinegoro Lubuk Buaya, 25586, Padang, Indonesia, Tel.: +62751481992
  • Tri Winarni Agustini Universitas Diponegoro, Faculty of Fisheries and Marine Sciences, Department of Fish Product Technology, Prof. H. Soedarto, 50275 , Semarang, Indonesia, Tel.: +62247474698
  • Kis Djamiatun Universitas Diponegoro, Faculty of Medicine, Department of Parasitology, Prof. Soedarto, 50275, Semarang, Indonesia, Tel.: +622476928010
  • Def Primal Universitas Perintis Indonesia, Faculty of Health Sciences, Department of Anatomy and Physiology, Adinegoro Lubuk Buaya, 25586, Padang, Indonesia, Tel.: +6281348305867 https://orcid.org/0000-0002-3553-6804

DOI:

https://doi.org/10.5219/1684

Keywords:

astaxanthin, HOMA-IR, antioxidant, T2DM, whiteleg shrimp shell powder

Abstract

As estimated having an increased incidence of about 50% until 2040, the diabetic condition could be augmented primarily from astaxanthin contained in carotenoids. This research examines and compares the influence of WSSP and AST complement on Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) level and Total Antioxidant Capacity (TAC) induced high-fat diet streptozotocin (HFD-STZ) in T2DM rats. WSSP 0.89gr/200gr/d (X1) and 1.77gr/200gr/d (X2) groups; and AST supplement 0.09mg/200gr/d (X3) groups were compared with both of positive (K1) and negative (K2) groups. The treatments were administered orally for 21 days to 25 Wistar rats which each group consisted of 5 rats. HOMA-IR and TAC levels were measured by ELISA and ABTs method respectively. TAC levels significantly increased in treatment groups than K1 group (p = 0.008). The increase in the TAC level of the X2 group was greater than the X1 group (p = 0.017). HOMA IR levels were significantly lower in treatment groups than K1 group (p = 0.009). X2 group had a greater decrease in HOMA IR levels compared to X1 (p = 0.016). In consequence, the research findings show a utilitarian effect of WSSP in increasing TAC and decreasing the HOMA-IR index.

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References

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Published

2021-09-28

How to Cite

Ahriyasna, R., Agustini, T. W., Djamiatun, K., & Primal, D. (2021). The improvement of insulin resistance and the antioxidant capacity in type 2 diabetes mellitus rats with whiteleg shrimp shell powder (Litopenaeus vannamei). Potravinarstvo Slovak Journal of Food Sciences, 15, 703–711. https://doi.org/10.5219/1684

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