Changes of plasma lipids in relation to the regular consumption of bilberries (Vaccinium myrtillus L.)
DOI:
https://doi.org/10.5219/233Keywords:
bilberries, total cholesterol, LDL cholesterol, HDL cholesterol, triacylglyceridesAbstract
In this work we studied the impact of regular consumption of bilberries on the lipid profile and triglycerides in the blood plasma. The research involved 18 women (average age 49.7) and 7 men (average age 52.8), who consumed 150 g of bilberries three times a week for 6 weeks. Based on these results, we can conclude that the average total cholesterol levels of women decreased from 5.65 mmol.l-1 at the beginning of research to 5.11 mmol.l-1. At end of the study, the average total cholesterol was 5.47 mmol.l-1. Similar results were found in the LDL cholesterol - the level of cholesterol of the second blood collection dropped from 4.06 mmol.l-1 to 3.70 mmol.l-1 and at the end of the study it increased again to 4.00 mmol.l-1. We observed a slight increase in HDL choleserol (by 0.07 mmol.l-1) and reduction of triglycerides (by 0.16 mmol.l-1). The total cholesterol monitored men due to the regular consumption of bilberries decreased by 0.36 mmol.l-1, LDL cholesterol by 0.31 mmol.l-1, HDL cholesterol by 0.49 mmol.l-1 and triglycerides by 0,49 mmol.l-1. The improvement of triglycerides and lipid profile in blood plasma of monitored subjects can by evaluated positively. The observed data confirm the biological activity of bilberries and the effectiveness of their use in prevention and comprehensive treatment of cardiovascular diseases.
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Basu, A., Du, M., Leyva, M. J., Sanchez, K., Betts, N. B., Wu, M., Aston, CH. E., Lyons, T. J. 2010a. Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome. J Nutr. vol. 140, no. 9, p.1582-1587. https://doi.org/10.3945/jn.110.124701 PMid:20660279
Basu, A., Rhone, M., Lyons TJ. 2010b. Berries: emerging impact on cardiovascular health. Nutr. Rev., vol 68, no. 3, p.168-177. https://doi.org/10.1111/j.1753-4887.2010.00273.x PMid:20384847
Burdulis, D., Ivanauskas, L., Dirsé, V., Kazlauskas, S., Ražukas, A. 2007. Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. Medicina, vol. 43, p.971-977. PMID:18182842
Carlsen, H., Myhrstad Mari, C. W., Thoresen, m., Moskaug, j. q., Blomhoff, r. 2003. Berry Intake Increases the Activity of the γ-Glutamylcysteine Synthetase Promoter in Transgenic Reporter Mice. J Nutr., vol. 133, no. 7, p. 2137-2140.
Carter, P., Gray, L. J., Troughton, J., Khunti, K., Davies, M. J. 2010. Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. BMJ [online]. 2010 Aug 18;341:c4229. [cit. 2011-07-07]. https://doi.org/10.1136/bmj.c4229 PMid:21421004
Čižmárová, M. 2009. Antioxidačná kapacita a antiradikálová aktivita vybraných druhov vín. Dizertačná práca. Nitra : SPU, 168 p.
Dauchet, L., Amouyel, P., Hercberg, S., Dallongeville, J. 2006. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr., vol. 136, no. 10, p. 2588-2593. PMid:16988131
Duthie, S. J., Jenkinson, A. McE., Crozier, A. et al. 2006. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Eur. J. Nutr., vol. 45, No. 2, p. 113-122. PMid:16032375
Evans, A., Tolonen, H., Hense, H. W., Ferrario, M., Sans S., Kuulasmaa, K. 2001. Who Monica trends in coronary risk factors in the WHO MONICA Project. Int. J. Epidemiol., vol. 30, suppl. 1, p. S35-S40. https://doi.org/10.1093/ije/30.suppl_1.S35 PMid:11759849
Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., Jula, A. 2008. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am. J. Clin. Nutr., vol. 87, no. 2, p. 323-331. PMid:18258621
Fábryová, F. 2002. Nové milénium - nové stratégie v prevencii a liečbe ischemickej choroby srdca: HDL cholesterol ako nový terapeutický cieľ. Cardiol., vol. 11, no. 5, p. 307-316.
Franeková, J., Friedecký, B., Jabor, A., Palička, V., Stožický, F., Soška V. 2006. Referenční meze, optimální a cílové hodnoty v kontextu klinického hodnocení lipidového profilu. Klin. Biochem. Metab., 14 (35), no. 4, p. 207-210.
Gordon, D. J., Probstfield, J. L., Garrison, R. J. et al. 1989. HDL cholesterol and cardiovascular disease. Four prospective American Studies. Circulation vol. 79, p.8-15. https://doi.org/10.1161/01.CIR.79.1.8 PMid:2642759
Habánová, m. 2011. Drobné ovocie ako významný zdroj antioxidantov vo výžive a profylaxii zdravia : habilitačná práca : SPU, 110 p.
Halliwell, B. 2009. The wanderings of a free radical. Free Rad. Biol. Med., vol. 46, no. 5, p. 531-542. https://doi.org/10.1016/j.freeradbiomed.2008.11.008 PMid:19111608
Hermsdorff, H. H, Zulet, M. A., Puchau, B., Martínez, J. A. 2010. Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutrition & Metabolism, vol.13, no. 7, p. 42. https://doi.org/10.1186/1743-7075-7-42
Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C. P., Sinaiko, A. R. 2009. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J.Am Diet Assoc., vol. 109, no. 3, p. 414-421. https://doi.org/10.1016/j.jada.2008.11.036 PMid:19248856
Huntley, A. L. 2009. The health benefits of berry flavonoids for menopausal women: Cardiovascular disease, cancer and cognition. Maturitas, vol. 63, no. 4, p. 297-301. PMid:19520526
Jaakola, L., Määttä-Riihinen, K., Kärenlampi, S., Hohtola, A. 2004. Activation of flavonoid biosynthesis by solar radiation in bilberry (Vaccinium myrtillus L.) leaves. Planta, vol. 218, no.5, p.721-728. https://doi.org/10.1007%2Fs00425-003-1161-x
Jennings, A., Welch, A. A., Fairweather, Tait, S. J. et al. 2012. Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women Am. J. Clin. Nutr., vol. 96, no. 4, p. 781-788. https://doi.org/10.3945/ajcn.112.042036 PMid:22914551
Jurkovičová, J. 2005. Vieme zdravo žiť? Univerzita Komenského v Bratislave : Bratislava, 166 s. ISBN 80-223-2132-X.
Kay, C. D., HOLUB, B. J. 2002. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status inhumansubjects. Bri. J. Nutr. Bri. J. Nutr., vol. 88, no. 4, p. 389-398., https://doi.org/10.1079/BJN2002665 PMid:12323088
Lätti, A. K., Riihinen, K. R., Kainulainen, P. S. 2008. Analysis of Anthocyanin Variation in Wild Populations of Bilberry (Vaccinium myrtillus L.). Finland J. Agric. Food. Chem., vol. 56, no. 1, p 190-196. https://doi.org/10.1021/jf072857m PMid:18072741
Manninen, V., Elo, M. D., Frick, M. H. Et al. 1988. Lipid alternations and decline in the incidence of coronary heart disease in the Helsinky Heart Study. In JAMA, vol. 206, p. 641-651. https://doi.org/10.1001/jama.1988.03410050061031 PMID:3164788
Määttä, Riihinen, K. R., Kamal, Eldin, A., Mattila, P. H., González-Paramás, A. M., Törrönen, A. R. 2004. Distribution and Contents of Phenolic Compounds in Eighteen Scandinavian Berry Species. J. Agric. Food. Chem., vol. 52, no. 14, p. 4477-4486. https://doi.org/10.1021/jf049595y PMID:15237955
Määttä-Riihinen, K. R., Kähkönen, M. P., Törrönen, A. R.,Heinonen, I. M. 2005. Catechins and procyanidins in berries of Vaccinium species and their antioxidant activity. J. Agric. Food. Chem., vol. 53, p. 8485-8491. https://doi.org/10.1021/jf050408l PMID:16248542
Michalska, M., Gluba, A., Mikhailidis, D. P., Nowak, P., Bielecka-Dabrowa, A., Rysz, J., Banach, M. 2010. The role of polyphenols in cardiovascular disease. Medical Science Monitor, vol. 16, no. 5, p. RA110-RA119. PMID:20424562
Moll, J. 2008. What are the health benefits of blueberries. [online]. [cit. 2008-12-5]. Retrieved from the web: <http://cholesterol.about.com/od/cgolesterol/nutrition101/a/blueberries.htm>.
Mosterd, A., Cost, B., Hoes, A. W., De Bruijne, M. C., Deckers, J. W., Hofman, A., Grobbee, D. E. 2001. The prognosis of heart failure in the general population: The rotterdam study. Eur. Heart J., vol. 22, no. 15, p.1318-1327. https://doi.org/10.1053/euhj.2000.2533 PMid:11465964
Mrázová, J. 2010. Deficit selénu vo výžive ľudí a jeho suplementácia v bravčovom mäse. Dizertačná práca. Nitra : SPU, 115 p.
NCEP ATP III. 2001. Executive Summary of the third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, vol. 285, no. 19, p.2486-2496. https://doi.org/10.1001/jama.285.19.2486 PMid:11368702
Pedersen, C. B., Kyle, J., Jenkinson, A. Mce., Gargner, P. T., Mcphail, D. B., Duthie, G. G. 2000. Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers. Eur. J. Clin. Nutr., vol. 54, no. 5, p. 405-408. https://doi.org/10.1038/sj.ejcn.1600972 PMid:10822287
Pomerleau, J., Mckee, M., Lobstein, T., Knai, C. 2003. The burden of disease attributable to nutrition in Europe. Public Health Nutrition, vol. 6, no. 5, p. 453-461. https://doi.org/10.1079/PHN2002456 PMid:12943561
Riboli, E., Norat, T. 2003. Epidemiologic evidence of the protection of the protective offect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr., vol. 78, no. 3, p. 559S-569S. PMid:12936950
Riihinen, K., Jaakola, L., Kärenlampi, S., Hohtola, A. 2008. Organ-specific distribution of phenolic compounds in bilberry (Vaccinium myrtillus) and 'northblue' blueberry (Vaccinium corymbosum x V. angustifolium). Food. Chem., vol. 110, no. 1, p.156-160. https://doi.org/10.1016/j.foodchem.2008.01.057,
Ruel, G., Pomerleau, S., Couture, P., Lamarche, B., Couillard C. 2005. Changes in plasma antioxidant capacity and oxidised low-density lipoprotein levels in men after short-term cranberry juice consumption. Metabolism, vol. 54, no. 7, p. 856-861. https://doi.org/10.1016/j.metabol.2005.01.031 PMid:15988692
Spencer, J. P. E., Vauzour, D., Rendeiro, C. 2009. Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects. Arch. Biochem. Biophys. vol. 492, no. 1-2, p. 1- 9. https://doi.org/10.1016/j.abb.2009.10.003 PMid:19822127
Stoclet, J. C., Chataigneau, T., Ndiaye, M., Oak, M. H., El Bedoui, J., Chataigneau, M., Schini-Kerth, V. B. 2004. Vascular protection by dietary polyphenols. Eur. J. Pharm., vol.500, no. 1-3, p. 299-313. https://doi.org/10.1016/j.ejphar.2004.07.034 PMid:15464042
Svensson, P., Sundberg, H., Lund, L.H., Stergren, J. 2010. Change in blood pressure during hospitalisation for acute heart failure predicts mortality. Scandinavian Cardiovascular Journal, vol. 44, no. 6, p. 325-330. https://doi.org/10.3109/14017431.2010.516367 PMid:21080863
Šimala, D. 2010. Čučoriedka chocholíkatá. [online]. [cit. 2010-12-4]. http://www.mountberry.sk/sk/pestovanie-ovocia/cucoriedka-chocholikata/.
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