Antioxidant, compositional evaluation and blood pressure modulating potentials of Bryophyllum pinnatum (Lam.), Viscum album (L.) and Artocarpus altilis (Parkinson) leave extracts
Keywords:antioxidant activity, benzesterol, phenol-1, 3-Dodecanol, piscofuranine
Bryophyllum pinnatum (Lam.), Viscum album (L.) and Artocarpus altilis (Parkinson) are medicinal plants widely used based on their ethnomedicinal properties in the regulation of blood pressure. This study was designed to evaluate the antioxidant activities and compositional constituents of these plants. The antioxidant potentials were analyzed using DPPH and FRAP assays, while Folin-Ciocalteu method was employed in the determination of the total phenolic antioxidant contents. Compositional analyses of the leave extracts were determined using Gas Chromatograghy-Mass Spectrophotometer (GC-MS). The total phenolic contents in Bryophyllum pinnatum, Artocarpus altilis and Viscum album were revealed as; 659.50 ±0.02, 1667.50 ±0.03, 1232.00 ±0.02 mg GAE.100 g-1 respectively. Considering the antioxidant activities, Artocarpus altilis leaf extract showed inhibitory activity on DPPH with IC50 of 2.24 ±0.26 mg.mL-1, Bryophyllum pinnatum and Viscum album with IC50 values 3.63 ±0.07 and 4.65 ±0.06 mg.mL-1 respectively.The FRAP in mg.GAE-1 for Artocarpus altilis, Bryophyllum pinnatum and Viscum album revealed; 2505.20 ±0.04, 1561.80 ±0.01 and 1698.00 ±0.03 respectively. GC-MS identified some vital phenolic components and essential fatty acids in the plants. The findings therefore suggest that; the plants if properly utilized, it could serve as alternatives in regulating blood pressure.
Abubakar, M. G., Yerima, M. B., Zahriya, A. G., Ukwuani-Kwaja, A. N. 2010. Acute toxicity and antifungal studies of ethanolic leaves, stem and pulp extract of Tamarindus indica. Research Journal of Pharmaceutical, Biological and Chemical Science, vol. 1, no. 4, p. 104-111.
AFNS. 2008. Alberta natural trans-fat research earns global recognition [online] s.a. [cit. 20018-01-05] Available at: https://www.topcropmanager.com/news/alberta-natural-trans-fat-research-earns-global-recognition-1440.
Afolabi, O. B., Oloyede, O. I. 2014. Antioxidant properties of the extracts of Talinum triangulare and its effects on antioxidant enzymes in tissue homogenate of Swiss albino rat. Toxicology International, vol. 21, no. 3, p. 307-313. https://doi.org/10.4103/0971-6580.155377 PMid:25948971 DOI: https://doi.org/10.4103/0971-6580.155377
Akanbi, T. O., Nazamid, S., Adebowale, A. A. 2009. Functional and pasting properties of a tropical breadfruit (A. altilis) starch from Ile-Ife, Osun State, Nigeria. International Food Research Journal, vol.1, no. 16, p. 151-157.
Beg, M., Sharma, V., Akhtar, N., Mohd, J. 2011. Role of Antioxidants in Hypertension. Journal, Indian Academy of Clinical Medicine, vol. 12, no. 2, p. 122-127.
Borris, R. P. 1996. Natural products research: perspectives from a major pharmaceutical company. Journal of Ethnopharmacology, vol. 51, no. 1-3, p. 29-38. https://doi.org/10.1016/0378-8741(95)01347-4 DOI: https://doi.org/10.1016/0378-8741(95)01347-4
Brand-Williams, W., Cuvelier, M. E., Berset, C. 1995. Use of a free radical method to evaluate antioxidant activity. LWT - Food Science and Technology, vol. 28, no. 1, p. 25-30. https://doi.org/10.1016/S0023-6438(95)80008-5 DOI: https://doi.org/10.1016/S0023-6438(95)80008-5
Grynberg, A. 2007. Hypertension prevention: from nutrients to (fortified) foods to dietary patterns. Focus on fatty acids. Journal of Human Hypertension, vol. 3, p. 25-33. DOI: https://doi.org/10.1038/sj.jhh.1001957
Hosseinzadeh, S., Jafarikukhdan, A., Hosseini, A., Armand, R. 2015. The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of Thymus vulgaris. International Journal of Clinical Medicine, vol. 6, no. 9, p. 635-642. https://doi.org/10.4236/ijcm.2015.69084 DOI: https://doi.org/10.4236/ijcm.2015.69084
Huang, D., Ou, B., Prior, R. L. 2005.The chemistry behind antioxidant capacity assays. Journal of Agricurtural and Food Chemistry, vol. 53, no. 6, p. 1841-1856. https://doi.org/10.1021/jf030723c PMid:15769103 DOI: https://doi.org/10.1021/jf030723c
Chan, E. W. C., Lim, Y. Y., Omar, M. 2007. Antioxidant and antibacterial activity of leaves of Etlingera species (Zingiberaceae) in Peninsular Malaysia. Food Chemistry, vol. 104, no. 4, p. 1586-1593. https://doi.org/10.1016/j.foodchem.2007.03.023 DOI: https://doi.org/10.1016/j.foodchem.2007.03.023
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izza, J L. Jr., Jones, D. W., Materson, B J., Oparil, S., Wright J. T. Jr., Roccella, E. J. 2003. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. The Journoal of the American Medical Association, vol. 289, no. 19, p. 2560-2571. https://doi.org/10.1001/jama.289.19.2560 PMid:12748199 DOI: https://doi.org/10.1001/jama.289.19.2560
Lans, C A. 2006. Ethnomedicine in Trinidad and Tobago for urinary problems diabetis mellitus. Journal of Ethnobiology nd Ethnomedicine, vol. 245, p. 157-168. DOI: https://doi.org/10.1186/1746-4269-2-45
Manach, C., Mazur, A., Scalbert, A. 2005. Polyphenols and prevention of cardiovascular disease. Current Opinion in Lipidology, vol. 16, no. 1, p. 77-84. https://doi.org/10.1097/00041433-200502000-00013 PMid:15650567 DOI: https://doi.org/10.1097/00041433-200502000-00013
Nwali, B. U., Okaka, A. N. C., Ibiam, U. A., Aja, P. M. 2012. Phytochemical compositon of B. pinnatum leaves. International Journal of Advanced Biotechnology and Research, vol. 2, no. 4, p. 614-616.
Okwu, D. E., Josiah, C. 2006. Evaluation of the chemical composition of two Nigerian medicinal plants. African Journal of Biotechnology, vol. 5, no. 4, p. 357-361.
Orwa, C., Mutua, A., Kindt, R., Jamnadass, S., Anthony, S. 2009. Agroforestree Database: A tree reference and selection guide. Version 4.0 World Agroforestry Centre, Kenya.
Sengul, M., Yildiz, H., Gungor, N., Cetin, B., Eser, Z., Ercisli, S. 2009. Total Phenolic Content, Antioxidant and Antimicrobial Activities of Some Medicinal Plants. Park Journal of Pharmacology Science, vol. 22, no. 1, p. 102-106.
Wang, Y., Chun, O. K., Song, W. O. 2013. Plasma and Dietary Antioxidant Status as Cardiovascular Disease Risk Factors: A Review of Human Studies. Nutritians, vol. 5, no. 8, p. 2969-3004. https://doi.org/10.3390/nu5082969 DOI: https://doi.org/10.3390/nu5082969
Wong, K., Juli, M., Russel, L. K., Cyril, W., Azadeh, J., David, J. 2006. Colonic Health:Fermentation and short chain fatty acids. Journal of Clinical Gastroenterology, vol. 40, no. 3, p. 235-243. https://doi.org/10.1097/00004836-200603000-00015 PMid:16633129 DOI: https://doi.org/10.1097/00004836-200603000-00015
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