Position of folic acid in fortification of nutrition in neonatal period


  • Tatiana Žikavská 1st Department of Pediatrics, Faculty of Medicine, Comenius University in Bratislava, Limbova 1, 833 40 Bratislava, Slovak Republic
  • Ingrid Brucknerová 1st Department of Peadiatrics, Faculty of Medicine, Comenius University in Bratislava, Limbova 1, 833 40 Bratislava




newborn, folic acid, fortification, milk fortifier


Folic acid is an essential vitamin which has been known in recent 50 years. It plays an important role in period of neurogenesis. The substitution of folic acid is one of the important parts in the complex treatment of anaemia in premature newborns. It is also a component of artificial milk formulae or breast milk following mother’s intake. Fortification of foods with folic acid for population in the world is still discussed. To determine optimal dose of folic acid in premature newborns is difficult. Daily recommended doses of folic acid in infants under the six months were identified. The needs of folic acid in newborns vary. It depends upon the gestational age, body reserves at birth or maternal status of folates during gravidity. On the other hand there is a risk of accumulation of unmetabolised folic acid in circulation of newborns after mandatory folic acid fortification in some countries, which were reported in some studies. The safe upper limits of folic acid intake in premature newborns are not known.

In this review article authors inform about the clear positive effect of folic acid in prenatal and neonatal period, but excessive doses of folic acid could present risk of accumulation and possible adverse effects. To follow up these notions further studies are required.


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How to Cite

Žikavská, T. ., & Brucknerová, I. . (2013). Position of folic acid in fortification of nutrition in neonatal period. Potravinarstvo Slovak Journal of Food Sciences, 7(1), 202–206. https://doi.org/10.5219/303