Influence of lifetime exposure of sublethal doses of cadmium to selected parameters of carbohydrate metabolism

Agnesa  Lukačí­nová; Jaroslava  Nováková; Eva  Lovásová; Iveta  Cimboláková; František  Ništiar

doi:10.5219/231

Authors

Agnesa Lukačínová Pavol Jozef Šafárik University Faculty of Medicine Department of Medicinal Physiology Trieda SNP 1 040 11 Košice
Jaroslava Nováková Pavol Jozef Šafárik University Faculty of Medicine Department of Pathological Physiology Trieda SNP 1 040 11 Košice
Eva Lovásová Pavol Jozef Šafárik University Faculty of Medicine Department of Pathological Physiology Trieda SNP 1 040 11 Košice
Iveta Cimboláková Pavol Jozef Šafárik University Faculty of Medicine Department of Pathological Physiology Trieda SNP 1 040 11 Košice
František Ništiar Pavol Jozef Šafárik University Faculty of Medicine Department of Pathological Physiology Trieda SNP 1 040 11 Košice

DOI:

https://doi.org/10.5219/231

Keywords:

low dose exposure, cadmium, haemoglobin, glucose, amylase, lactate dehydrogenase

Abstract

The aim of the study was to assess the effects of exposure to low doses of cadmium dissolved in drinking water (at a concentration 200 times higher than the maximum permissible dose) on selected parameters of carbohydrate metabolism in 20 Wistar rats. Animals were divided into two groups – control and experimental groups exposed to low doses of cadmium chloride in concentration 20 μM of drinking water. We studied the biochemical parameters, as glucose, hemoglobin, glycated hemoglobin, lactate dehydrogenase and amylase in blood of rats. Glucose, hemoglobin, glycated hemoglobin and amylase levels increased, lactate dehydrogenase was no changed of rats exposed to cadmium. Good indicators of chronic intoxication by cadmium are elevated levels of glucose, hemoglobin and mainly glycated hemoglobin in blood. The evaluation results should be taken into account not only the data at the end of the experiment but for the entire duration of trials (i.e., more time steps), which results largely make objective.

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