The correlation of intake phytate and tannin on serum transferrin receptor and hemoglobin in stunted overweight adolescents

Authors

  • La Mani Diponegoro University, Faculty of Medicine, Department of Nutrition Science, Semarang, Indonesia 50275, Tel : +6285255069739 https://orcid.org/0000-0001-7462-3540
  • Siti Fatimah-Muis Diponegoro University, Faculty of Medicine, Department of Nutrition Science, Semarang, Indonesia 50275, Tel : +628122867895
  • Apoina Kartini Diponegoro University, Faculty of Public Health, Ministry of Public Health, Semarang, Indonesia, Diponegoro University, Faculty of Medicine, Department of Nutrition Science, Semarang, Indonesia 50275, Tel : +628122939166

DOI:

https://doi.org/10.5219/1191

Keywords:

Stunted overweight, sTfR, Hemoglobin, Fitat, Tannin

Abstract

Stunted overweight teenagers are at risk of having iron deficiency. Iron deficiency is caused by various factors including the high food absorption inhibitors of iron such as phytate and tannins. Phytate and tannin contain polyphenol compounds which have a strong ability to bind iron so that it inhibits iron absorption in the intestine. This study aims to analyze the correlation between phytate, tannin intake and serum transferrin receptor (sTfR) and hemoglobin in stunted overweight adolescents. The research method was a cross-sectional study of 64 stunted overweight adolescents selected by consecutive sampling in four high schools/vocational high schools in Banyumanik District, Semarang City. Phytate and tannin intake data using SQ-FFQ method. The serum transferrin receptor examination uses the ELISA method and the hemoglobin level uses the Cyanomethemoglobin method. The results of the study, most of the respondents had high phytate and tannin intake of 96.9% and 89.1%. Respondents with low serum transferrin receptor were 7.8% and low hemoglobin levels were 7.8%. There was no  correlation between phytate intake with serum transferrin receptor or hemoglobin (p1 = 0.937 r1 = -0.010, p2 = 0.192 r2 = 0.165). Tannins were significantly correlated with serum transferrin receptor and hemoglobin (p1 = 0.005 r1 = 0.344, p2 = 0.002 r2 = -0.374). Based on multivariate analysis, tannin is a determinant of hemoglobin (R2 = 0.257). Conclusion is that tannin is positively correlated with serum transferrin receptor and hemoglobin in stunted overweight adolescents. Excessive tannin intake can cause deficiency in stunted overweight adolescents.

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References

Afifah, Y. N., Sulchan, M., Nissa, C. 2017. Trigliserida/High Density Lipoprotein-Cholesterol Ratio In Adolescent Stunted Obesity Ages 15-18 Years In Semarang City. J. Nutr. Coll., vol. 6, no. 2, p. 172-179. https://doi.org/10.14710/jnc.v6i2.16907 DOI: https://doi.org/10.14710/jnc.v6i2.16907

Aigner, E., Feldman, A., Datz, C. 2014. Obesity as an emerging risk factor for iron deficiency. Nutr., vol. 6, no. 9, p. 3587-3600. https://doi.org/10.3390/nu6093587 DOI: https://doi.org/10.3390/nu6093587

Armah, S. M., Boy, E., Chen, D., Candal, P., Reddy, M. B. 2015. Regular Consumption of a High-Phytate Diet Reduces the Inhibitory Effect of Phytate on Nonheme-Iron Absorption in Women with Suboptimal Iron Stores. Nutr., vol. 145, no. 8, p. 1735–1739. https://doi.org/10.3945/jn.114.209957 DOI: https://doi.org/10.3945/jn.114.209957

Association of Clinical Pathologists. 1996. SI-Conventional unit system conversion table and Adult-Child reference value Clinical Laboratory Parameters. Jakarta.

Balitbang, K. 2013. Basic Health Research. Jakarta.

Brown, J. E. 2011 Nutrition Through The Life Cycle. 4th Ed. Wadsworth, USA : Cengage Learning, 516 p. ISBN-13 978-0538733410.

Cashin, K., Oot, K. 2018. Guide To Anthropometry A Practical Tool for Program Planners, Managers, and Implementers. Washington, DC.

Dahlan, M. S. 2011. Statistics for Medicine and Health. Jakarta : Salemba Medika.

Dumith, S. C., Gigante, D. P., Domingues, M. R., Kohl, H. W. 2011 Physical activity change during adolescence: a systematic review and a pooled analysis. Int. J. Epidemiol., vol. 40, no. 3, p. 685-698. https://doi.org/10.1093/ije/dyq272 DOI: https://doi.org/10.1093/ije/dyq272

Feeley, A., Musenge, E., Pettifor, J. M., Norris, S. A. 2012. Changes in dietary habits and eating practices in adolescents living in urban South Africa: the birth to twenty Cohort. Nutr., vol. 28, no. 7-8, p. 1-6. https://doi.org/10.1016/j.nut.2011.11.025 DOI: https://doi.org/10.1016/j.nut.2011.11.025

Habánová, M., Lorková, M., Kopčeková, J. 2010. The consumption of acidophylus drinks and yogurts in selected population of pupils in years 2004 and 2008. Potravinarstvo Slovak Journal of Food Sciences, vol. 4, no. 3, p. 19-23. https://doi.org/10.5219/26 DOI: https://doi.org/10.5219/26

Hallberg, L., Brune, M., Rossander, L. 1989. Iron absorption in an: Ascorbic acid and dose dependent inhibiton by phytate. Am. J. Clin. Nutr., vol. 49, no. 1, p. 140-144. https://doi.org/10.1093/ajcn/49.1.140 DOI: https://doi.org/10.1093/ajcn/49.1.140

Hassan, T. H., Badr, M. A., Karam, N. A., Zkaria, M. E., Saadany, H. F., Rahman, D. M., Shahbah, D. A., Selim, A. M., Morshedy, S. A., Fathy, M., Wsh, A. M. H. 2016. Impact of iron deficiency anemia on the function of the immune system in children. J. Med., vol. 47, no. 47, p. 1-5. https://doi.org/10.1097/MD.0000000000005395 DOI: https://doi.org/10.1097/MD.0000000000005395

Hoffman, D. J., Sawaya, A. L., Verreschi, I., Tucker, K. L., Roberts, S.B. 2000. Why are nutritionally stunted children at increased risk of obesity? Studies of metabolic rate and fat oxidation in shantytown children from Sao Paulo. Brazil. Am. J. Clin. Nutr., vol. 72, no. 7, p. 702-707. https://doi.org/10.1093/ajcn/72.3.702 DOI: https://doi.org/10.1093/ajcn/72.3.702

Hotz, C., Gibson, R. S. 2007. Traditional Food-Processing and Preparation Practices to Enhance the Bioavailability of Micronutrients in Plant-Based Diets. J. Nutr., vol. 137, no. 4, p. 1097-100. https://doi.org/10.1093/jn/137.4.1097 DOI: https://doi.org/10.1093/jn/137.4.1097

Hurrel, R., Engli, I. 2010. Iron bioavailability and dietary reference values. Am. J. Clin. Nutr., vol. 91, no. 5, p. 1461S-1467S. https://doi.org/10.3945/ajcn.2010.28674F DOI: https://doi.org/10.3945/ajcn.2010.28674F

Indriasari, R. M., Jafar, N. 2015. The consumption of tannin and phytate as a determinant of the causes of anemia in adolescent girls in SMA Negeri 10 Makassar. J. M. K. M. I., vol. 3, p. 50-58.

Kruger, H. S., Margetts, B. M., Vorster, H. H. 2004. Evidence for relatively greater subcutaneous fat deposition in stunted girls in the North West Province, South Africa, as compared with non-stunted girls. Nutr., vol. 20, no. 6, p. 564-569. https://doi.org/10.1016/j.nut.2004.03.002 DOI: https://doi.org/10.1016/j.nut.2004.03.002

Kruger, H. S., Pretorius, R., Schutte, A. E. 2010. Stunting, adiposity, and low-grade inflammation in African adolescents from a township high school. Nutr., vol 26, no. 1, p. 90-99. https://doi.org/10.1016/j.nut.2009.10.004 DOI: https://doi.org/10.1016/j.nut.2009.10.004

Kumar, V., Shinta, A. K., Harinder, P. S., Makkar, K. B. 2010. Dietary roles of phytate and phytase in human nutrition: A review. Food Chem., vol. 120, no. 4, p. 945-959. https://doi.org/10.1016/j.foodchem.2009.11.052 DOI: https://doi.org/10.1016/j.foodchem.2009.11.052

Mukuddem-Petersen, J. M., Kruger, H. S. 2014 Association between stunted and overweight among 10–15-y-old children in the North West Province of South Africa: the Thusa Bana Study. Int. J. Assoc. Study. Obes., vol. 28, p. 842-851 https://doi.org/10.1038/sj.ijo.0802586 DOI: https://doi.org/10.1038/sj.ijo.0802586

Nelson, M., Poulter, J. 2004. Impact of tea drinking on iron status in the UK: A review. J. Hum. Nutr. Diet, vol. 17, no. 1, p. 43-54. https://doi.org/10.1046/j.1365-277X.2003.00497.x DOI: https://doi.org/10.1046/j.1365-277X.2003.00497.x

Reddy, N. R., Shridhar, K. S. 2002. Food Phytates. Washington : CRC Press, 280 p. ISBN-13 978-1566768672.

Santoso, B., Sulistiowati, E., Sekartuti, Lamid, A. 2013 Basic Health Research in Central Java Province. Jakarta

Saraswati, A. T., Sulchan, M. 2016. Occurrence of metabolic syndrome in stunted obesity adolescent girls in Rural Jepara. J. Nutr. Coll., vol. 3 p. 192-199.

Sastroasmoro, S., Ismael, S. 2014 Basics of Clinical Research Methodology. 5th ed. Jakarta : Sagung Seto.

Sotelo, A., Gonzales-Osnaya, L., Sanchesz-Chinchilla, A. T. 2010. Role of oxate, phytate, tannins and cooking on iron bioavailabilty from foods commonly consumed in mexico. Int J. Food Nutr., vol 61, no. 1, p. 29-39. https://doi.org/10.3109/09637480903213649 DOI: https://doi.org/10.3109/09637480903213649

Stanojevic, S., Kain, J., Uauy, R. 2007. The Association Between Changes in Height and Obesity in Chil ean Preschool Children : 1996 - 2004. J. Obesity., vol. 15, no. 4, p. 1012-1022. https://doi.org/10.1038/oby.2007.611 DOI: https://doi.org/10.1038/oby.2007.611

Sumarmi, S., Puspitasari, N., Handajani, R., Wirjatmadi, B. 2016. Underweight as a Risk Factor for Iron Depletion and Iron- Deficient Erythropoiesis among Young Women in Rural Areas of East Java, Indonesia. Mal. J. Nutr., vol. 22, no. 2, p. 219-232.

Thankachan, P., Walczyk, T., Muthayya, S., Kurpad, A. V., Hurrell, R. F. 2008. Iron absorption in young Indian women : the interaction of iron status with the influence of tea and ascorbic acid. Am. J. Clin. Nutr., vol. 87, no. 4, p. 881-886. https://doi.org/10.1093/ajcn/87.4.881 DOI: https://doi.org/10.1093/ajcn/87.4.881

Urrechaga, E., Borque, L., Escanero, J. F. 2013. Biomarkers of hypochromia: The contemporary assessment of iron status and erythropoiesis. Bio. Med. Res. Int., vol. 2013, p. 1-8. https://doi.org/10.1155/2013/603786 DOI: https://doi.org/10.1155/2013/603786

Zimmermann, M. B., Hurrell, R. F. 2007. Nutritional iron deficiency. The Lancet, vol. 370, no. 9586, p. 511-520. https://doi.org/10.1016/S0140-6736(07)61235-5 DOI: https://doi.org/10.1016/S0140-6736(07)61235-5

Published

2019-11-28

How to Cite

Mani, L., Fatimah-Muis, S., & Kartini, A. (2019). The correlation of intake phytate and tannin on serum transferrin receptor and hemoglobin in stunted overweight adolescents. Potravinarstvo Slovak Journal of Food Sciences, 13(1), 870–874. https://doi.org/10.5219/1191