Assessment of the effect of bioactive nutrients and probiotic microorganisms on the parameters of lipid metabolism in the body
DOI:
https://doi.org/10.5219/1685Keywords:
bioactive nutrient, lipid metabolism, LDL cholesterol, HDL cholesterol, triglycerideAbstract
The aim of the work is a comparative study of the effect of vegetable nutrients - wheat germ oil (WGO), flour from wheat germ cake (WGC), and animal - concentrated tissue fish oil, origin on lipid metabolism indicators of students and university teachers, as well as an assessment of the probiotic factor in increasing the effectiveness of the target biologically active substances. The data obtained confirm the relation between the nutritional sufficiency of the body and the increase in lipid metabolism effectiveness and atherosclerosis risk reduction in students and teachers of an engineering university with the daily use of bioactive nutrients: WGO, WGCF, CTFO and their combinations with the biomass of lactobacilli and bifidobacteria consortium. The lipid metabolism was evaluated based on the analysis of indicators of the total cholesterol (TC) concentrations, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides (TG), atherogenic index (AI). The values of these indicators were recorded before and after daily consuming the study foods for 30 days. The data obtained were analyzed for 3 age groups: 16 – 24, 25 – 44, and 45 – 65. It was found that WGO has the most effective antiatherosclerotic effect; the decrease in the TC level was 6.4%, the increase in the HDL concentration was 13.7%, the decrease in the LDL concentration was 11.3%, the decrease in the TG concentration was 17.1%, and the AI decreased by 22.6%, respectively. With WGCF, the changes in the studied parameters were 6.0, 12.3, 13.1, 13.1, and 22.1%, respectively. Together with probiotics WGO effectiveness increased in terms of the reduced TC level (1.9%), increased HDL concentration (8.2%), decreased LDL concentration (2.5%), reduced TG concentration (5.7%), and decreased AI (6.3%) for CTFO by 9.1, 26.1, 14.7, 24.1 and 31.2%, respectively. Thus, the dynamics of lipid metabolism indices objectively testifies to the positive effect of bioactive nutrients on human health indicators.
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Angelin, J., Kavitha, M. 2020. Exopolysaccharides from probiotic bacteria and their health potential. International Journal of Biological Macromolecules, vol. 162, p. 853-865. https://doi.org/10.1016/j.ijbiomac.2020.06.190 DOI: https://doi.org/10.1016/j.ijbiomac.2020.06.190
Arabidze, G. G., Tebloev, K. I. 2008. Atherosclerosis and risk factors. Moscow, Russian Federation : Geotar-Media, 240 p. ISBN978-5-98216-092-8.
Arruzazabala, M., Carbajal, D. 2012. Cholesterol-lowering effects of policosanol in rabbits. Biological Research, vol. 27, p. 205-209. https://doi.org/10.1079/bjn19970090 DOI: https://doi.org/10.1079/BJN19970090
Arruzazabala, M., Valdes, S., Mas, R. 2013. Effect of policosanol successive dose increase in platelet aggregation healthy volunteers. Pharmacolical Research, vol. 34, 181-185. https://doi.org/10.1006/phrs.1996.0086 DOI: https://doi.org/10.1006/phrs.1996.0086
Bouillon, R., Antonio, L. 2020. Nutritional rickets: Historic overview and plan for worldwide eradication. The Journal of Steroid Biochemistry and Molecular Biology, vol. 198, p. 105–115. https://doi.org/10.1016/j.jsbmb.2019.105563 DOI: https://doi.org/10.1016/j.jsbmb.2019.105563
Boukid, F., Folloni, S., Ranieri, R., Vittadini, E. 2018. A compendium of wheat germ: Separation, stabilization and food applications. Trends in Food Science & Technology, vol. 78, p. 120-133. https://doi.org/10.1016/j.tifs.2018.06.001 DOI: https://doi.org/10.1016/j.tifs.2018.06.001
Canetti, M., Morera, M., Illnait, J. 2012. Estudiocomparativo de los efectos del policosanol y el gemfibrozil enpacientes con hiper-colesterolemiatipo II. Rev. (Comparative study of the effects of policosanol and gemfibrozil in patients with type II hypercholesterolemia. Rev) CENIC Cicn. Biol., vol. 27, p. 64-70.
Carbajal, D., Arruzazabala, M., Mas, R. 2012. Effect of policosanol on experimental thrombosis models. Prostaglandins Leuko. Essent. Fatty Acids, vol. 50, p. 249-251. https://doi.org/10.1016/0952-3278(94)90162-7 DOI: https://doi.org/10.1016/0952-3278(94)90162-7
Cenit, M. C.,Matzaraki, V., Tigchelaar, E., F., Zhernakova, A. 2014. Rapidly expanding knowledge on the role of the gut microbiome in health and disease. Biochimica et Biophysica Acta – Molecular Basis of Disease, vol. 1842, p. 1981-1992. https://doi.org/10.1016/j.bbadis.2014.05.023 DOI: https://doi.org/10.1016/j.bbadis.2014.05.023
Chugh, B., Kamal-Eldin A. 2020. Bioactive compounds produced by probiotics in food products. Current Opinion in Food Science, vol. 32, p. 76-82. https://doi.org/10.1016/j.cofs.2020.02.003 DOI: https://doi.org/10.1016/j.cofs.2020.02.003
Grigoriev, Yu. D. 2015. Optimal experiment design methods: linear models. Moscow, Russian Federation : Lan’, 320 p. ISBN978-5-8114-1937-1
Heshmati, J., Morvaridzadeh, M., Maroufizadeh, S., Akbari, A., Yavari., M., Amirinejad, A., Maleki-Hajiagha, A., Sepidarkish, M. 2019. Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials. Pharmacological Research, vol. 149, p. 1-19.https://doi.org/10.1016/j.phrs.2019.104462 DOI: https://doi.org/10.1016/j.phrs.2019.104462
Isaev, V. A., Simonenko, S. V. 2016. The influence of lifestyle and Eikonol on the physiological adaptation of the fatty component of blood in arterial hypertension. Nutrition Issues, vol. 85, no. 5, p. 120-127.
Jamshidi, A., Cao, H., Xiao, J., Simal-Gandara, J. 2020. Advantages of techniques to fortify food products with the benefits of fish oil. Food Research International, vol. 137, p. 1-17. https://doi.org/10.1016/j.foodres.2020.109353 DOI: https://doi.org/10.1016/j.foodres.2020.109353
Longo, R., Ferrari, A., Zocchi, M. 2017. Of mice and humans through the looking glass: “reflections” on epigenetics of lipid metabolism. Molecular Aspects of Medicine, vol. 54, p. 16-27. https://doi.org/10.1016/j.mam.2017.01.005 DOI: https://doi.org/10.1016/j.mam.2017.01.005
Meerson, F. Z., Belkina, L. M., Isaev, V. A., Vertkin, A. L., Saltykova, A. A. 1993. Influence of tissue fish oil with a high content of omega-3 PUFA on lipid peroxidation, arrhythmias and mortality in acute ischemia, reperfusion and myocardial infarction in experiment. Cardiology, vol. 3, p. 43-48.
Mohammed Farugue, A. 2018. Ganoderma lucidum: persuasive biologically active constituents and their health endorsement. Bio-medicine and Pharmacotherapy, vol. 107, p. 507-519. https://doi.org/10.1016/j.biopha.2018.08.036 DOI: https://doi.org/10.1016/j.biopha.2018.08.036
Popov, E. S., Rodionova, N. S., Sokolova, O. A., Mazurenko, N. Yu. 2016. Assessment of the prospects for the production of products balanced in polyunsaturated fatty acids from domestic vegetable raw materials. Hygiene and Sanitation, vol. 95, no. 1, p. 79-84. https://doi.org/10.18821/0016-9900-2016-95-1-79-84 DOI: https://doi.org/10.18821/0016-9900-2016-95-1-79-84
Rodionova, N. S., Alekseeva, T. V. 2015. Technologies of food products of balanced PUFA composition: a monograph. Voronezh, Russian Federation : Voronezh State Uni-versity of Engineering Technologies Press, 256 p.
Rodionova, N. S., Alekseeva, T. V., Popov, E. S., Kalgina, Yu. O., Natarova, A. A. 2016. Hygienic aspects and prospects of domestic production of products of wheat germ deep processing. Hygieneand Sanitation, vol. 95, no. 1, p. 74-79. https://doi.org/10.18821/0016-9900-2016-95-1-74-79 DOI: https://doi.org/10.18821/0016-9900-2016-95-1-74-79
Rodionova, N. S., Isaev, V. A., Vishnyakov, A. B., Popov, E. S., Safonova, N. V. 2016. Storublevtsev, S. A. Influence of wheat germ cake oil and flour on the lipid metabolism indicators in students and university teachers. Nutrition Issues, vol. 85 no. 6, p. 60-66.
Rodionova, N. S., Popov, E. S., Razinkova, T. A. 2019a. Investigation of the process of exopolysaccharides synthesis by lacto – and bifidobacteria consortium in the dairy environment. In Proceeding of the 19th International Multidisciplinary Scientific Geoconference SGEM 2019. Varna, Bulgaria: STEF92 Technology, p. 777-783. ISSN 1314-2704. https://doi.org/10.5593/sgem2019/6.1/S25.100 DOI: https://doi.org/10.5593/sgem2019/6.1/S25.100
Rodionova, N. S., Popov, E. S., Rodionova, N. A. 2019b. Emulsifying properties of probiotic systems enriched with plant biocorrectors. Actual Biotechnology, vol. 3, p. 313-314.
Rodionova, N. S., Popov, E. S., Sokolova, O. A. 2016. Nutrient correctors of the nutritional status based on deep processed products of low-oil raw materials: a monograph. Voronezh, Russian Federation : Voronezh State University of Engineering Technologies Press, 240 p.
Rodionova, N. S., Popov, E. S., Syromyatnikov, M. Y., Artemova, E. A. 2019c. Alimentary factors for the correction of nutritional status and physiological conditions. In Proceeding of the 1st International Symposium on Innovations in Life Sciences (ISILS 2019). Belgorod, Russian Federation: Atlantis Press, p. 262-265. ISBN 978-94-6252-840-6 https://doi.org/10.2991/isils-19.2019.64 DOI: https://doi.org/10.2991/isils-19.2019.64
Roobab, U., Batool, Z., Manzoor, M. F., Shabbir, M. A., Khan, M. R., Aadil R. M. 2020. Sources, formulations, advanced delivery and health benefits of probiotics. Current Opinion in Food Science, vol. 32, p. 17-28. https://doi.org/10.1016/j.cofs.2020.01.003 DOI: https://doi.org/10.1016/j.cofs.2020.01.003
Spector, A. A., Kim, H-Y. 2019. Emergence of omega-3 fatty acids in biomedical research. Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 140, p. 47-50. https://doi.org/10.1016%2Fj.plefa.2018.11.017 DOI: https://doi.org/10.1016/j.plefa.2018.11.017
Teneva-Angelova, T., Hristova, I., Pavlov, A., Beshkova, D. 2018. Chapter 4 - lactic acid bacteria—from nature through food to health. In Grumezescu, A.,Holban,A. M. Advances in Biotechnology for Food Industry. Cambridge, USA : Academic Press, p. 91-133. ISBN 9780128114438 https://doi.org/10.1016/B978-0-12-811443-8.00004-9 DOI: https://doi.org/10.1016/B978-0-12-811443-8.00004-9
Vishnyakov, A. B. Rodionova, N. S. Isaev, A. V., Popov, E. S., Belokurova, E. V., Rodionova, N. A., Interesova, E. A. 2020. Nutrition. Energy. Entropy: a monograph. Voronezh, Russian Federation: Voronezh State University of Engineering Technologies Press, 286 p.
Vishnyakov, A. B., Vlasov, V. N., Rodionova, N. S., Alekseeva, T. V., Popov, E. S., Dyakov, A. A. 2018. The embryo of health: a monograph, 2nd ed., revised and supplemented. Voronezh, Russian Federation: Voronezh State University of Engineering Technologies Press, 286 p.
Yang, Z.-H., Amar, M., Sorokin, A. V., Troendle, J., Courville, A. B., Sampson, M., Playford, M. P., Yang, S., Stagliano, M., Ling, C., Donkor, K., Shamburek, R. D., Mehta, N. N., Remaley, A. T. 2020. Supplementation with saury oil, a fish oil high in omega-11 monounsaturated fatty acids, improves plasma lipids in healthy subjects. Journal of Clinical Lipidology, vol. 14, p. 53-65. https://doi.org/10.1016/j.jacl.2019.10.013 DOI: https://doi.org/10.1016/j.jacl.2019.10.013
Zamroziewicz, M., Tanveer Talukdar, M., Zwilling, C., Barbey, A. 2017. Nutritional status, brain network organization, and general intelligence. NeuroImage, vol. 161, p. 241-250. https://doi.org/10.1016/j.neuroimage.2017.08.043 DOI: https://doi.org/10.1016/j.neuroimage.2017.08.043
Zuo, F., Chen, S., Marcotte, H. 2020. Engineer probiotic bifidobacteria for food and biomedical applications – Current status and future prospective. Biotechnology Advances, vol. 45, p. 1-12. https://doi.org/10.1016/j.biotechadv.2020.107654 DOI: https://doi.org/10.1016/j.biotechadv.2020.107654
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