Satureja montana L. essential oil various dosages effect on the main rats’ biological features

Vladimir Pashtetsky; Pavel Ostapchuk; Elena Usmanova; Eugenia Zyablitskaya; Tatiana Makalish; Irina Danilova; Tatiana Kuevda; Denis Zubochenko; Veronica Uppe; Aleksandra Pashtetskaia; Anna Pikhtereva; Viktor Abalduev; Vitalii Delov; Alina Posobilova

doi:10.5219/1643

Authors

Vladimir Pashtetsky Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“ The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Pavel Ostapchuk Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Elena Usmanova Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Eugenia Zyablitskaya Central Research Laboratory, Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
Tatiana Makalish Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
Irina Danilova Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007 https://orcid.org/0000-0001-9311-1479
Tatiana Kuevda Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Denis Zubochenko Laboratory of Molecular Genetics, Proteomics and Bioinformatics in Agriculture, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Veronica Uppe Laboratory of Molecular Genetics, Proteomics and Bioinformatics in Agriculture, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007 https://orcid.org/0000-0001-5978-045X
Aleksandra Pashtetskaia Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Anna Pikhtereva Processing and Standardization of Essential Oil Raw Materials Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
Viktor Abalduev Junior Researcher, Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
Vitalii Delov Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
Alina Posobilova Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170 https://orcid.org/0000-0002-9554-5307

DOI:

https://doi.org/10.5219/1643

Keywords:

Satureja montana L., essential oil, rats, live weight, plasma, stomach, liver

Abstract

An application of natural antioxidants remains the focus of research groups. The effect of Satureja montana L. essential oil in various doses on the main biological characteristics of Wistar rats was the main aim of the study. The intensification of protein metabolism in the blood plasma of rats on the background of the use of Satureja montana L. essential oil was noted. Total protein increases by 17.9 – 19.7%, and albumin by 27.6% in rats of the experimental group received the essential oil at a dose of 0.6 ml per kg of feed. A significant increase in the AST level in control group rats to 207.3 U.L^-1 was revealed. Its one to a certain extent indicates the hepatoprotective effect of mountain savory oil and a decrease in inflammatory processes in the organs of the gastrointestinal tract in the conditions of cell maintenance of rats of the experimental groups. Gastric epithelium thickness of rats of both experimental groups was lower than the control animals. But it did not bear any signs of atrophy. The difference of this indicator in comparison with control was 12.75 μm (p ≤0.05) in the second group and it was reliable. The number of chief stomach cells increases in animals of the experimental groups, which may indicate a greater enzymatic activity. An increased dose of mountain savory oil contributes to the formation of more damage to hepatocytes on the periphery of the liver lobule. Thus, the relationship between liver enzymes and the state of peripheral hepatocytes was noted.

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