TY - JOUR AU - Fauza, Ahdiyatul AU - Al-Baarri, Ahmad Ni'matullah AU - Djamiatun, Kis PY - 2019/08/28 Y2 - 2024/03/28 TI - Potency of Okra flour (Abelmoschus esculentus) in improving adiponectin level and total antioxidant capacity of high fat diet streptozotocin rat model JF - Potravinarstvo Slovak Journal of Food Sciences JA - Potr. S. J. F. Sci. VL - 13 IS - 1 SE - Articles DO - 10.5219/1136 UR - https://potravinarstvo.com/journal1/index.php/potravinarstvo/article/view/1136 SP - 644-650 AB - <p>T2DM has increase in global-morbidity and mortality. Oxidative stress and adiponectin-levels are important for insulin-resistance and pancreatic-b-cell-dysfunction in T2DM. Okra fruit is rich of quercetin and phytosterol which have positive-effect for T2DM. Research aimed was to study the effect of okra-flour to adiponectin-levels and total-antioxidant-capacity (TAC) in T2DM. Thirty Wistar-rats were divided randomly in five groups. K1 and (X1, X2 and X3)-treated-groups were in T2DM-condition-induced by high-fat-diet-(HFD)-Streptozotochin-(STZ)-nicotinamid-(NA). Healthy-controls-(K2)-group was also used. Okra-flour was given orally for 28 days at doses of 0.1; 0.2 and 0.3 g/Kg-body-weight/d to X1, X2 and X3-groups, respectively. Statistical program was used to analyse the different between pre-post-intervention, and between groups. Correlations between variables were also analysed. The serum-adiponectin and TAC-levels were measured by ELISA and ABTS-methods, respectively. By comparing pre and post-intervention, adiponectin levels of all-intervention-(X1, X2, X3)-group were&nbsp; increase (<em>p</em> = 0.027 for X1 and X2; <em>p</em> = 0.028 for X3), while in the same period the decrease were found in group K1 (<em>p</em> = 0.026) and K2 (<em>p</em> = 0.028). Increase-TAC-levels pre-post-intervention was observed in group all-intervention-groups (<em>p</em> = 0.027), while no change in K1 (<em>p</em> = 0.66) and the decrease in group K2 (<em>p</em> = 0.039). Reduce-fasting-blood-glucose-levels pre-post-intervention were shown in the all-intervention-groups (<em>p</em> = 0.028), while for the K1 groups was increase (<em>p</em> = 0.028). There were significant differences between the five-groups on fasting-blood-glucose-levels, adiponectin and TAC-levels, and X3-group showed the highest adiponectin and TAC-levels. Very-strong-correlations were found between glucose-adiponectin-TAC-levels-post-intervention. Okra-flour make better glucose-adiponectin and TAC-levels in T2DM-conditions. Okra dose of 0.30 g/Kg-body-weight/day is the best in increasing adiponectin and TAC-levels.</p> ER -